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KMID : 1101320070390030271
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Korean Journal of Clinical Laboratory Science
2007 Volume.39 No. 3 p.271 ~ p.276
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Clinical Usefulness of 14C-Urea Breath Test for the Diagnosis of H. pylori Infection
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Kim Yoon-Sik
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Abstract
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Helicobacter pylori (H. pylori) infection is common in korea and high incidence at gastric ulcer and duodenal ulcer. 14C-urea breath test (14C-UBT) is regarded as a highly reliable and non-invasive method for the diagnosis of H. pylori infection. The purpose of this study was to evaluate the diagnositc performance of a new and rapid 14C-UBT, which was equipped with Geiger-Muller counter and compared the results with those obtained by gastroduodenoscopic biopsies (GBx). One hundred sixty-eight patients (M : F = 118 : 50) underwent 14C-UBT, rapid urease test (CLO test), and GBx. The results of 14C-UBT were classified as positive (>50 cpm), borderline (2514C-UBT or CLO test results with GBx as a glod standard. In the assessment of the presence of H. pylori infection, the 14C-UBT global performance yielded positive predictive value, negative predictive value and accuracy of 93.3% and 83.3%, respectively. However, the CLO test had performance yielded positive predictive value, negative predictive value and accuracy of 76.9%, 50.0%, respectively. In this study 14C-UBT is a highly accurate, simple and non-invasive method or the diagnosis of follow up H. pylori infection.
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KEYWORD
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Helicobacter pylori, 14C-urea breath test, Gastroduodenoscopic biopsies
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